As long as human beings place all their trust in material realizations they will be disappointed because given their nature, these things do not last.
So, they should set material preoccupations aside for a while and do their utmost to reach the most inaccessible Being, God himself, or their higher Self, so that it may descend and manifest in them.
Then, yes, they will experience true accomplishments, inner realizations in their consciousness that are immediate and lasting. To achieve such realizations, concentrate on a sublime ideal which you know in advance will never materialize on the physical plane.
Inwardly however, you will experience this realization; you will live it in that very instant, and it will never leave you.